The upcoming pHealth 2019 is the 16th event in a series of international conferences on personalized health, to cater to the needs of medical professionals, the health care industry, caregivers, and patients including their social circles. But at the same time, it is about facilitating the engagement and empowerment of all “players” in the entire domain of health (care). Having started back in 2003 with personal health management systems as technology focused International Conference on Wearable Micro and Nano Technologies for Personalized Health, pHealth has evolved to a truly interdisciplinary meeting combining medicine, technologies, biomedical engineering, legal, ethical, social, and organizational aspects and impacts with basic research for enabling future care paradigms. It brings together internationally recognized experts on the one hand and young scientists on the other hand. That way, pHealth increasingly bridges between advanced medical services, public health and epidemiological monitoring, prevention, social and elderly care, as well as wellness and fitness. These activities aim at establishing participatory, predictive, personalized, preventive precision medicine and effective care settings. Smart mobile systems, health apps, sensors native or attached to mobile phones available to eHealth and telemedicine are emerging as enablers for ubiquitous pervasive health and the main components for the next wave of health services delivering integrated care, so still presenting advances in wearable or implantable micro-, nano- and biotechnologies for healthcare and wellness. Social media and gamification further highlight the potential of pHealth. The 2019 edition of pHealth will emphasize the interrelated aspects framing ubiquitous pervasive health: mobile technologies, wellness, micro-nano-bio smart system, bio-data management and analytics for personalized health, precision medicine and virtual care. It also addresses new potential risks for security and privacy as well as safety chances and challenges, the motivation of patients in care processes by game and gamification, and health systems challenges in developing countries. The intended outcome is intelligent and connected health devices and services leading to integrated care. The multilateral benefits of pHealth technologies for all stakeholder communities give enormous potential, not only for medical quality improvement and industrial competitiveness, but also for managing health care costs and, last but not least, improving patient experiences. The 2019 Italian version will include workshops and related pre-conference Summer Schools for graduates and PhD students in the field, and it will showcase the Italian healthcare system and related EU and national projects. The event is hosted by the Department of Informatics, Bioengineering, Robotics and System Engineering (DIBIRS) of the University of Genoa, one of the largest universities in Italy. The organizers would like to welcome you for pHealth 2019 to the city Genoa, an important area for science and industry as well as research and development in Italy. Please join us to share your expectations, experiences, projects, and results, and to open our domain up for the digitized future!